8,019 research outputs found
Real-time optical manipulation of cardiac conduction in intact hearts
Optogenetics has provided new insights in cardiovascular research, leading to new methods for cardiac pacing, resynchronization therapy and cardioversion. Although these interventions have clearly demonstrated the feasibility of cardiac manipulation, current optical stimulation strategies do not take into account cardiac wave dynamics in real time. Here, we developed an allâoptical platform complemented by integrated, newly developed software to monitor and control electrical activity in intact mouse hearts. The system combined a wideâfield mesoscope with a digital projector for optogenetic activation. Cardiac functionality could be manipulated either in freeârun mode with submillisecond temporal resolution or in a closedâloop fashion: a tailored hardware and software platform allowed realâtime intervention capable of reacting within 2 ms. The methodology was applied to restore normal electrical activity after atrioventricular block, by triggering the ventricle in response to optically mapped atrial activity with appropriate timing. Realâtime intraventricular manipulation of the propagating electrical wavefront was also demonstrated, opening the prospect for realâtime resynchronization therapy and cardiac defibrillation. Furthermore, the closedâloop approach was applied to simulate a reâentrant circuit across the ventricle demonstrating the capability of our system to manipulate heart conduction with high versatility even in arrhythmogenic conditions. The development of this innovative optical methodology provides the first proofâofâconcept that a realâtime optically based stimulation can control cardiac rhythm in normal and abnormal conditions, promising a new approach for the investigation of the (patho)physiology of the heart
An electromagnetic shashlik calorimeter with longitudinal segmentation
A novel technique for longitudinal segmentation of shashlik calorimeters has
been tested in the CERN West Area beam facility. A 25 tower very fine samplings
e.m. calorimeter has been built with vacuum photodiodes inserted in the first 8
radiation lengths to sample the initial development of the shower. Results
concerning energy resolution, impact point reconstruction and electron/pion
separation are reported.Comment: 13 pages, 12 figure
Debris disks in main sequence binary systems
We observed 69 A3-F8 main sequence binary star systems using the Multiband
Imaging Photometer for Spitzer onboard the Spitzer Space Telescope. We find
emission significantly in excess of predicted photospheric flux levels for
9(+4/-3)% and 40(+7/-6)% of these systems at 24 and 70 microns, respectively.
Twenty two systems total have excess emission, including four systems that show
excess emission at both wavelengths. A very large fraction (nearly 60%) of
observed binary systems with small (<3 AU) separations have excess thermal
mission. We interpret the observed infrared excesses as thermal emission from
dust produced by collisions in planetesimal belts. The incidence of debris
disks around main sequence A3-F8 binaries is marginally higher than that for
single old AFGK stars. Whatever combination of nature (birth conditions of
binary systems) and nurture (interactions between the two stars) drives the
evolution of debris disks in binary systems, it is clear that planetesimal
formation is not inhibited to any great degree. We model these dust disks
through fitting the spectral energy distributions and derive typical dust
temperatures in the range 100--200 K and typical fractional luminosities around
10^-5, with both parameters similar to other Spitzer-discovered debris disks.
Our calculated dust temperatures suggest that about half the excesses we
observe are derived from circumbinary planetesimal belts and around one third
of the excesses clearly suggest circumstellar material. Three systems with
excesses have dust in dynamically unstable regions, and we discuss possible
scenarios for the origin of this short-lived dust.Comment: ApJ, in press. 57 pages, including 7 figures (one of which is in
color
Identification of a novelABCD1 mutation in a family with Adrenoleukodistrophy
X-linked adrenoleukodistrophy (X-ALD) is the most common peroxisomal disorder. The disease is caused by muta>ons in the ABCD1 gene that encodes the peroxisomal membrane protein ALDP which is involved in the transmembrane transport of very long-chain faGy acids (VLCFA; >22). A defect in ALDP results in elevated levels of VLCFA in plasma and >ssues. The clinical spectrum in males with X-ALD ranges from isolated adrenocor>cal insufficiency and slowly progressive myelopathy to devasta>ng cerebral demyelina>on. The majority of heterozygous females will develop symptoms by the age of 60 years. We describe a family with six members carrying a novel heterozygous muta>on IVS4+2T>A (c.1393+2T>A) of the ABCD1 gene highligh>ng the wide range of phenotypic manifesta>ons of ALD
An electromagnetic shashlik calorimeter with longitudinal segmentation
A novel technique for longitudinal segmentation of shashlik calorimeters has been tested in the CERN West Area beam facility. A 25 tower e.m. calorimeter has been built with vacuum photodiodes inserted in the first 8 radiation lengths to sample the initial development of the shower. Results concerning energy resolution, impact point reconstruction and separation are reported.A novel technique for longitudinal segmentation of shashlik calorimeters has been tested in the CERN West Area beam facility. A 25 tower very fine samplings e.m. calorimeter has been built with vacuum photodiodes inserted in the first 8 radiation lengths to sample the initial development of the shower. Results concerning energy resolution, impact point reconstruction and electron/pion separation are reported
A shashlik calorimeter with longitudinal segmentation for a linear collider
Two techniques for longitudinal segmentation of shashlik calorimeters are proposed. Beam tests have demonstrated the technical feasibility of longitudinally segmented shashlik calorimeters in which longitudinal sampling is performed by lateral vacuum photodiodes or by using two scintillator types with different decay times. Results concerning energy resolution and e/Ï separation are presente
Cross Sections for the Reactions e+e- --> K+ K- pi+pi-, K+ K- pi0pi0, and K+ K- K+ K- Measured Using Initial-State Radiation Events
We study the processes e+e- --> K+ K- pi+pi-gamma, K+ K- pi0pi0gamma, and K+
K- K+ K-gamma, where the photon is radiated from the initial state. About
84000, 8000, and 4200 fully reconstructed events, respectively, are selected
from 454 fb-1 of BaBar data. The invariant mass of the hadronic final state
defines the \epem center-of-mass energy, so that the K+ K- pi+pi- data can be
compared with direct measurements of the e+e- --> K+ K- pi+pi- reaction. No
direct measurements exist for the e+e- --> K+ K-pi0pi0 or e+e- --> K+ K-K+ K-
reactions, and we present an update of our previous result with doubled
statistics. Studying the structure of these events, we find contributions from
a number of intermediate states, and extract their cross sections. In
particular, we perform a more detailed study of the e+e- --> phi(1020)pipigamma
reaction, and confirm the presence of the Y(2175) resonance in the phi(1020)
f0(980) and K+K-f0(980) modes. In the charmonium region, we observe the J/psi
in all three final states and in several intermediate states, as well as the
psi(2S) in some modes, and measure the corresponding product of branching
fraction and electron width.Comment: 35 pages, 42 figure
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Measurement of B(B-->X_s {\gamma}), the B-->X_s {\gamma} photon energy spectrum, and the direct CP asymmetry in B-->X_{s+d} {\gamma} decays
The photon spectrum in B --> X_s {\gamma} decay, where X_s is any strange
hadronic state, is studied using a data sample of (382.8\pm 4.2) \times 10^6
e^+ e^- --> \Upsilon(4S) --> BBbar events collected by the BABAR experiment at
the PEP-II collider. The spectrum is used to measure the branching fraction B(B
--> X_s \gamma) = (3.21 \pm 0.15 \pm 0.29 \pm 0.08)\times 10^{-4} and the
first, second, and third moments = 2.267 \pm 0.019 \pm 0.032 \pm
0.003 GeV,, )^2> = 0.0484 \pm 0.0053 \pm 0.0077 \pm
0.0005 GeV^2, and )^3> = -0.0048 \pm 0.0011 \pm 0.0011
\pm 0.0004 GeV^3, for the range E_\gamma > 1.8 GeV, where E_{\gamma} is the
photon energy in the B-meson rest frame. Results are also presented for
narrower E_{\gamma} ranges. In addition, the direct CP asymmetry A_{CP}(B -->
X_{s+d} \gamma) is measured to be 0.057 \pm 0.063. The spectrum itself is also
unfolded to the B-meson rest frame; that is the frame in which theoretical
predictions for its shape are made.Comment: 37 pages, 19 postscript figures, submitted to Phys. Rev. D. No
analysis or results have changed from previous version. Some changes to
improve clarity based on interactions with Phys. Rev. D referees, including
one new Figure (Fig. 13), and some minor wording/punctuation/spelling
mistakes fixe
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